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Impact of HDAC inhibitors on macrophage polarization to enhance innate immunity against infections
Innate immunity plays an important role in host defense against pathogenic infections. It involves macrophage polarization into either the pro-inflammatory M1 or the anti-inflammatory M2 phenotype, influencing immune stimulationorsuppression, respectively.Epigeneticchangesduring immune reactions contribute to long-term innate immunity imprinting on macrophage polarization.
Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors
HDAC8 can mediate signals by using its enzymatic or nonenzymatic functions, which are expected to be critical for various types of cancer. Herein, we employed proteolysis targeting chimera (PROTAC) technology to target the enzymatic as well as the nonenzymatic functions of HDAC8.
Host-directed therapies modulating innate immunity against infection in hematologic malignancies
Patients with hematologic malignancies (HM) are highly susceptible to bloodstream infection (BSI), particularly those undergoing treatments such as chemotherapy. A common and debilitating side effect of chemotherapy is oral and intestinal mucositis.
Histone Deacetylase 3-Directed PROTACs Have Anti-inflammatory Potential by Blocking Polarization of M0-like into M1-like Macrophages
Macrophage polarization plays a crucial role in inflammatory processes. The histone deacetylase 3 (HDAC3) has a deacetylase-independent function that can activate pro-inflammatory gene expression in lipopolysaccharide- stimulated M1-like macrophages and cannot be blocked by traditional small-molecule HDAC3 inhibitors.
AMR DAY 2024 was a special event organized by the EU-funded IN-ARMOR project as part of Antimicrobial Resistance Week 2024
During this event, five European Commission-funded projects dedicated to combating antimicrobial resistance came together to share their initiatives, challenges, and results. Here, we can see talks of VÉSALE BIOSCIECNE and UNIVERSITY OF ICELAND.
