11 Mar, 2025.
From the IN-ARMOR project we are proud to announce the participation of Faizan Bhat / University of Groningen in the Gordon Research Conference on Antimicrobial Peptides (Ventura, California) presenting the project
11-03-2025
Innate immunity is the first line of defense against infections, with macrophages playing a key role through their polarization into pro inflammatory (M1 or anti inflammatory (M2 phenotypes This balance dictates immune activation or suppression.
Recent research highlights the role of epigenetic modulators, such as histone deacetylase (inhibitors HDACi in shaping macrophage responses to infections In addition, antimicrobial peptides (natural defense molecules with potent antimicrobial and immunomodulatory properties are gaining attention as crucial players in immune regulation AMPs not only directly combat pathogens but also influence macrophage function enhancing immune responses.
This review explores the impact of HDACi and other epigenetic modulators on macrophage polarization in diseases with strong immune components Specific HDACs, including HDAC 1 HDAC 2 HDAC 3 HDAC 6 and HDAC 8 regulate the M1/M 2 balance, offering potential therapeutic targets By integrating epigenetic regulation with AMP based strategies we can develop innovative approaches to strengthen innate immunity particularly against drug resistant infections
